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A steroidal androgen receptor blocker, spironolactone is effective for hormonal acne and hirsutism. It is generally given concomitantly with oral contraceptives. Spironolactone may cause menstrual irregularities (usually metrorrhagia). Normal menses may resume with a reduction of the dosage. Spironolactone may also feminize a male fetus, which is another reason it should be administered with oral contraceptives.

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